Sonia Kadima

Email: info@icbc.ie

Sonia Kadima I completed a BSc honors degree in Medical Biochemistry at the University of Cape Town in South Africa and an MSc in Molecular Biology at the University of Leuven in Belgium. I am particularly interested in the regulation of tone in the urethra as tone is affected by ion channels, and is a potential mechanism for drug action. Myogenic tone in urethra smooth muscle is regulated by several neurotransmitters, including noradrenaline, acetylcholine, nitric oxide and potentially ATP. The aim of my work is to investigate the mechanisms underlying ATP regulation in the urethra and its implications on the regulation of calcium activity and hence on tone. I am also investigating how the oscillations of calcium seen in muscle strips from urethra are regulated, using calcium imaging techniques.  An important aspect is to look at the effect of application of drugs on oscillatory activity and the difference between the role of specialized cells known as interstitial cells of Cajal, and on smooth muscle. My research also employs Molecular Biology and Immunohistochemistry techniques to examine the expression of specific receptors in urethra smooth muscle, with a hope of aiding in the development of knowledge for future drug treatment in human disease as I continue to move toward completion of her PhD.

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