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Claire Doyle

Email: info@icbc.ie

Claire Doyle I work with highly specialized cells known as Interstitial Cells of Cajal (ICC), and investigate their activity in the corpus cavernosum, which is a sponge-like region of erectile tissue. To accomplish this, I use techniques for cell dispersion to isolate single ICCs and record electrical activity using a method known as the perforated patch clamp technique. This method enables whole cell patch clamp recordings to be undertaken without a complete tearing of the cell wall in the area located below the electrode. This less invasive technique has enabled me to record ion channel currents in isolated ICCs and observe the effects of drugs on their activity with minimal disturbance to intracellular environments. I have also used this fragile tissue in tension recording apparatus and have adapted classical techniques to specific research needs. Moving forward toward the completion of my PhD, I will use confocal imaging techniques to observe the movement of ions within the tissue and correlate these findings with my research to date, to assist in developing treatments for diseased tissue.  I was trained at Trinity College, Dublin and graduated with a BSc in Physiology.

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